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Feyi-Waboso's autumn international campaign was ended early by concussion before he dislocated his shoulder on club duty
BBC Sport rugby union news reporter
England wing Immanuel Feyi-Waboso will make his return against a France XV on Saturday after six months out though injury.
The 22-year-old Exeter flier dislocated his shoulder against Sale in December and suffered a setback during an international training camp before having an operation.
Bath flankers Ted Hill and Guy Pepper also start after playing key roles in last weekend's Premiership final victory over Leicester, with Saracens' Tom Willis between them at number eight.
Sale's Joe Carpenter is at full-back and Gloucester's Seb Atkinson at 12, but both will have to wait for his first cap with the match against a second-string French outfit not being classified as a Test.
Fly-half George Ford and hooker Jamie George co-captain the side while Northampton's Alex Coles, who last appeared for England during the tour of New Zealand last summer, earns a shot in the second row.
The Harlequins forward trio of Chandler Cunningham-South, Jack Kenningham and Alex Dombrandt are on the bench, alongside Sale scrum-half Raffi Quirke.
England are without their 13 British and Irish Lions tourists, who are preparing for Friday's warm-up against Argentina and the tour of Australia.
With Fin Smith and Marcus Smith both touring with the Lions, in-form Ford has a chance to stake a claim to the 10 shirt that he last wore at the end of the 2024 Six Nations.
Ben Curry, Fraser Dingwall, George Furbank and Harry Randall are all working their way back from injury in the camp, while Ollie Lawrence, Ollie Sleightholme and George Martin are longer-term absentees.
England: Carpenter; Roebuck, Slade, Atkinson, Feyi-Waboso; Ford (co-c), Spencer; Baxter, George (co-c), Heyes, Coles, Isiekwe, Hill, Pepper, Willis
Replacements: Dan, Rodd, Davison, Cunningham-South, Kenningham, Dombrandt, Quirke, Beard
Feyi-Waboso scored five tries in his previous eight England appearances and was nominated for World Rugby's Breakthrough of the Year award after a stellar 2024.
He was a strong contender for Lions selection before his injury and coach Andy Farrell has left open the possibility of adding to his party if players return to form and fitness.
Gael Fickou, Nolann Le Garrec, Cameron Woki and Theo Attissogbe were among those named in a 28-strong French squad for the match last weekend.
Coach Fabien Galthie is without a clutch of stars with the Top 14 semi-finals featuring Toulouse, Bordeaux-Begles, Toulon and Bayonne taking place on the same weekend.
The match serves as a warm-up for the teams' respective summer tours with England taking on Argentina in a two-Test series and the United States in a one-off match in Washington DC. The squad for that tour England will be announced on Monday.
France, meanwhile, will play three matches against New Zealand in July.